CURE ( C lopidogrel in U nstable angina to prevent R ecurrent ischemic E vents): an international study of patients presenting to hospital with an acute coronary syndrome (unstable angina or myocardial infarction without ST segment elevation). Patients were randomized to clopidogrel or matching placebo 300mg loading dose followed by clopidogrel or matching placebo 75mg daily for the duration of follow-up. All patients received ASA in a dose range of 75mg-325mg daily at the discretion of the investigator. 12,562 patients from 28 countries and from 482 clinical centres were enrolled over a period of approximately 20 months. The last patient was randomized to CURE on September 7, 2000 and the study end date was then determined as December 6, 2000. The preliminary results of the study were presented at the American College of Cardiology, Late Breaking Clinical Trials session on March 19, 2001.